Correspondence: SEMA4A variation and risk of colorectal cancer
نویسندگان
چکیده
of colorectal cancer Ben Kinnersley1, Daniel Chubb1, Sara E. Dobbins1, Matthew Frampton1, Stephan Buch2, Maria N. Timofeeva3, Sergi Castellvı́-Bel4, Susan M. Farrington3, Asta Forsti5, Jochen Hampe6, Kari Hemminki5, Robert M.W. Hofstra7,8, Emma Northwood9, Claire Palles10, Manuela Pinheiro11, Clara Ruiz-Ponte12, Clemens Schafmayer13, Manuel R. Teixeira11, Helga Westers8, Tom van Wezel14, D. Timothy Bishop9,
منابع مشابه
Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X
Familial colorectal cancer type X (FCCTX) is characterized by clinical features of hereditary non-polyposis colorectal cancer with a yet undefined genetic background. Here we identify the SEMA4A p.Val78Met germline mutation in an Austrian kindred with FCCTX, using an integrative genomics strategy. Compared with wild-type protein, SEMA4A(V78M) demonstrates significantly increased MAPK/Erk and PI...
متن کاملCorrespondence: Reply to 'SEMA4A variation and risk of colorectal cancer'.
Kinnersley et al. comment on our recently published study1 and report a failure to support semaphorin A (SEMA4A) variations as risk alleles for colorectal cancer (CRC)2. The authors investigated the contribution of the recurrent SEMA4A variants p.Gly484Ala (rs148744804) and p.Pro682Ser (rs76381440) in cohorts of CRC cases from different European populations. No significant association could be ...
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2016